Dysregulation of ubiquitin homeostasis and beta-catenin signaling promote spinal muscular atrophy
نویسندگان
چکیده
Citation for published version: Wishart, TM, Mutsaers, CA, Riessland, M, Reimer, MM, Hunter, G, Hannam, ML, Eaton, SL, Fuller, HR, Roche, SL, Somers, E, Morse, R, Young, PJ, Lamont, DJ, Hammerschmidt, M, Joshi, A, Hohenstein, P, Morris, GE, Parson, SH, Skehel, PA, Becker, T, Robinson, IM, Becker, CG, Wirth, B & Gillingwater, TH 2014, 'Dysregulation of ubiquitin homeostasis and beta-catenin signaling promote spinal muscular atrophy' Journal of Clinical Investigation, vol 124, no. 4, pp. 1821-1834. DOI: 10.1172/JCI71318
منابع مشابه
Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy.
The autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA) results from low levels of survival motor neuron (SMN) protein; however, it is unclear how reduced SMN promotes SMA development. Here, we determined that ubiquitin-dependent pathways regulate neuromuscular pathology in SMA. Using mouse models of SMA, we observed widespread perturbations in ubiquitin homeostasis, inc...
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